Selasa, 30 Maret 2010

[P582.Ebook] Download PDF Physiology of Non-Excitable Cells: Proceedings of the 28th International Congress of Physiological Sciences, Budapest, 1980: Physiology of

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Physiology of Non-Excitable Cells: Proceedings of the 28th International Congress of Physiological Sciences, Budapest, 1980: Physiology of

Advances in Physiological Sciences, Volume 3: Physiology of Non-Excitable Cells is a collection of papers presented at the 28th International Congress of Physiology, held in Budapest on July 13-19, 1980. This book is organized into five parts encompassing 36 chapters that cover the various physiological aspects of non-excitable cells and neuronal membranes.

The first two parts describe cellular models of iso-osmotic and epithelial transport. The third part highlights the relationship between cell transport and cellular metabolism. This part also deals with the genetic and hormonal control of cellular transport, as well as the lipoprotein synthesis and secretion by hepatocyte. The fourth part explores cell-to-cell communication through junctional membrane channels and calmodulin. The fifth part examines the temporal structure of biological systems in the sub-second time domains.

This book will be of value to physiologists, cell biologists, researchers, and biology students.

  • Sales Rank: #3838864 in eBooks
  • Published on: 2013-10-22
  • Released on: 2013-10-22
  • Format: Kindle eBook

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Minggu, 28 Maret 2010

[O101.Ebook] Free Ebook Classic Sourdoughs, Revised: A Home Baker's Handbook, by Ed Wood, Jean Wood

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Classic Sourdoughs, Revised: A Home Baker's Handbook, by Ed Wood, Jean Wood

Sourdough: The Gold Standard of Bread
 
More and more home bakers are replacing mass-produced breads and commercial yeasts in favor of artisan breads made with wild cultures and natural fermentation. Whether you want to capture your own local yeasts, take advantage of established cultures like San Francisco Sourdough, or simply bake healthier, more natural loaves, you’ll find no better guides than renowned sourdough authorities Ed and Jean Wood.
 
In this updated edition of Classic Sourdoughs, the Woods reveal their newly discovered secret to crafting the perfect loaf: by introducing a unique culture-proofing step and adjusting the temperature of the proofs, home bakers can control the sourness and leavening like never before. The reward? Fresh, hot sourdough emerging from the oven just the way you like it—every time. Starting with their signature Basic Sourdough loaf, the Woods present recipes featuring rustic grains and modern flavors, including Herb Spelt Bread, Prarie Flax Bread, and Malt Beer Bread, along with new no-knead versions of classics like White French Bread. They round out the collection with recipes for homemade baguettes, bagels, English muffins, and cinnamon rolls, plus a chapter on baking authentic sourdoughs in bread machines.
 
Steeped in tradition, nuanced in flavor, and wonderfully ritualized in preparation, sourdough is bread the way it was meant to be. So join the sourdough renaissance and bring these time-honored traditions into your own kitchen.

  • Sales Rank: #10912 in Books
  • Published on: 2011-07-12
  • Released on: 2011-07-12
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.20" h x .50" w x 7.40" l, .75 pounds
  • Binding: Paperback
  • 192 pages

Review
Praise for the PREVIOUS edition

“[The] new edition of Wood’s classic global explorations of wild yeast is a big event
in the baking world and a must for sourdough fans.” 
—The Arizona Republic

“Brings the tradition of sourdough cooking into focus. It is easy, interesting reading and doesn’t make sourdough baking seem complicated.” 
—Sharon Maasdam, The Oregonian

About the Author

ED WOOD, MD, PhD, is a physician and research scientist whose quest for ancient sourdough cultures began in Saudi Arabia, where he served as a chairman of pathology at a Riyadh hospital. He returned to the United States with a bevy of sourdough cultures and began blending the art of baking with the rigor of science. He and his wife, JEAN WOOD, founded Sourdoughs International, which ships sourdough cultures from Cascade, Idaho, to seventy-eight countries around the world.

Excerpt. © Reprinted by permission. All rights reserved.
INTRODUCTION

THIS BOOK WILL introduce you to the personal satisfaction and sense of accomplishment experienced by home bakers of traditional sourdough. If you are an experienced sourdough baker, it will guide you to the sourdoughs you seek.
 
Let’s start by defining what we really mean by “traditional” sourdoughs. We know the sourdough process results from the fermentation reactions of two quite different classes of microorganisms: wild yeast and beneficial bacteria. For well over five thousand years, all breads were produced by the fermentation of these two essential microorganisms acting together. The yeasts are primarily responsible for leavening and bread texture, the bacteria for the sourdough flavor. Thus the definition of “traditional” sourdough requires a “culture,” or “starter,” containing both of these organisms.
 
Delicious, nutritious breads of various kinds were produced for centuries by a process no one understood. Bakers believed there was “something” in dough that made it rise. They knew if they saved some old dough and added it to a new batch, the new dough would also rise. For eons, all new doughs required a bit of old dough to “start” the rising process. In villages and towns around the world, bread was the staff of life—it literally supported life. People baked it in their homes, and every town had a bakery where the people could take their dough to be baked in the baker’s oven, or buy bread from the baker himself. When people emigrated to the United States, they brought their dough starters with them. The California forty-niners and the Yukon and Alaskan miners get credit for the term “sourdoughs,” probably due to the extreme flavor of their breads (the crusty miners themselves subsequently became known as “sourdoughs”). Thus our definition of “traditional” sourdough also requires a culture with organisms that, with proper care, will survive and replicate themselves forever.
 
In the 1800s, Louis Pasteur looked into a microscope and saw what we now call wild yeast, discovering for the first time what really made bread dough rise. Within the next hundred years, researchers learned how to select, isolate, and grow single strains of yeast in pure cultures. They searched for and found species of Saccharomyces cerevisiae, baker’s yeast, which leavened bread doughs with incredible speed. Then industry took bread out of the home and put it in factories that manufacture something labeled “bread,” which neither looks nor tastes like the staff of life. Breads began to be produced by mammoth machines. Sourdough starters were no longer used, small-town bakeries disappeared, people stopped baking in their homes, and the staff of life became neither delicious nor nutritious. Bakers thought the need for sourdough cultures was gone forever, but they were wrong. Baker’s yeast is totally incapable of producing sourdough flavor, and without the action of lactobacilli in concert with yeast, the quality of breads has never been the same—not even close.
 
Within just the last hundred years, there have been monumental changes to what we call bread, and these changes are mostly for the worse. Not only do huge baking machines now dominate the production of bread, the baking industry adds a plethora of chemicals to flour and dough to change their physical characteristics and improve their “machinability.” These include surface-active agents (surfactants) to help doughs go through machinery without sticking or tearing, other chemicals to soften the final bread texture or strengthen the dough by modifying the gluten, and a host of emulsifiers just to improve the mixing characteristics or increase shelf life. All of these additives have one thing in common: no, or very limited, nutritional value. At least one of them, potassium bromate, has been banned worldwide as a potential carcinogen.
 
In centralized industrial bakeries, large baking conglomerates produce packaged breads and refrigerated or frozen dough for distribution to retail stores and local bakeries. The distribution of industrial bread doughs means that even if a bread is baked fresh at a local bakery, it often still contains all the additives and chemicals included by the wholesale producers to grease its progress through the massive machinery—and none of the beneficial microflora that make bread taste like bread. And this is not only an American story: the deterioration of bread quality is a worldwide phenomenon, occurring even in the European heartlands of great bread.
In spite of these monumental changes, a small cadre of hardy souls have continued using the old-fashioned sourdough methods and today they are widely celebrated as “artisan” bakers. They have persisted in baking traditional sourdoughs, and in the past few decades, the market for their products has blossomed. Industrial bread still lumbers on, dominating the market, but it is easier now than it has been in many years to find real, old-fashioned sourdough breads—or to make them at home.
 
The best breads available today are being produced in the home or in artisan bakeries. But in our kitchens, the techniques are not the same as those used by the artisan bakers, or by the pioneers. Early home bakers used their starters to bake almost every day. Most of us now start with a culture that has become dormant between uses. The production capacity of the artisan baker requires masonry or special ovens and equipment beyond the scope of the individual home baker. For that reason, this book is designed specifically for and dedicated to the individual who bakes for him or herself or for a family and who deserves the thrill and joy of traditional sourdoughs.
 
 
ONE
 
The Birth and Life of Sourdough
 
It took uncounted centuries for wheat and other grains used for flour to evolve. Jarmo, in the uplands of Iraq, is one of the oldest archaeological excavations in the Middle East, dating to about 8000 BC. Here, archaeologists have identified carbonized kernels and clay imprints of plants that resemble wild and domesticated wheats. Historians believe that similar grains were established in Egypt by at least the same time, and perhaps as early as 10,000 to 15,000 BC. Rye existed in the Middle East as an unwanted weed and eventually spread across the Mediterranean to the Baltic countries, where it dominates bread making to this day. These wild grasses took millennia to progress to grain-producing plants, and it was many centuries before humans learned to cultivate and use them for food.
 
Grains like wheat and rye were probably first consumed as porridge. Eventually, this gruel evolved into a flat cake of baked cereal—baked perhaps on a hot rock in the fire. But how did these flat, hard cakes rise for the first time and become bread? An unbaked cake, perhaps forgotten on a warm summer evening, would be a perfect medium for contamination by an errant wild yeast. Imagine how many times that accident occurred before someone saw it and then baked it! It must have taken a thousand years, a thousand accidents, and finally a thousand experiments to produce a recognizable loaf of bread.
 
 
The Discovery of Yeast
 
In 1676, a Dutch lens grinder, Anton van Leeuwenhoek, first observed and described microscopic life, and in 1680, he produced the first sketches of yeast in beer. But for the next 170 years, nothing more happened to further our understanding of bread’s secrets. Then in 1857, Louis Pasteur proved that fermentation is caused by yeast, and a comprehensive system of yeast classification, which we still use, was published in 1896. With Pasteur’s work, a whole new field of yeast technology and cereal chemistry came to life. Microbiologists learned how to isolate single yeast cells and to select pure cultures. They selectively bred wild strains to develop yeast cells that leavened faster, were more tolerant to temperature change, and were easier to produce commercially. Modern mass-produced cakes of pressed yeast and packages of active dried yeast contain billions of cells that are all exactly alike. These purified strains are carefully guarded to prevent contamination by wild types.
 
Cereal chemists were at work, too, learning to control the texture and appearance of bread by bleaching and blending different types of flour. They found a host of chemical additives to improve the consistency of dough and change its flavor, and to increase the shelf life of the finished loaf and improve its nutritional value. Agronomists selected for and bred wheat varieties that resist disease, produce bigger yields per acre, contain more protein, and so on. These advances all contributed to the industrial production of bread, with huge machines producing thousands of loaves per day. Now a handful of very large bakeries produce more than three-fourths of all bread sold in the United States. These same “advances” have also resulted in the fact that most modern bread has the flavor of an edible napkin.
 
Yeasts are microfungi and are much larger than most bacteria. More than 350 different species exist, with countless additional strains and varieties. In the century and a half since Louis Pasteur discovered that yeast fermentation produces carbon dioxide, which leavens dough, yeasts have been studied in every conceivable light and harnessed to perform hundreds of different tasks, from cleaning up oil slicks to producing antibiotics. Many yeast strains are industrially produced for very specific functions, including commercial bread making. It is important to understand the basic differences between the wild yeasts of sourdough and the commercial baker’s yeast used in most other breads. First, sourdough yeasts grow best in acidic doughs, while baker’s yeast does better in neutral or slightly alkaline doughs. Baker’s yeast is a single species, Saccharomyces cerevisiae, with hundreds of strains and varieties, while sourdoughs are usually leavened by one or more species in the same dough, none of them baker’s yeast. Baker’s yeast is a highly uniform product that produces an equally uniform texture in bread dough. The wild yeasts are anything but uniform, and they vary from region to region. But perhaps the most impressive difference between the two yeast types is that a single package of instant dried yeast produces just one batch of bread, while the same amount of wild sourdough culture produces loaf after loaf for the lifetimes of many bakers.
 
In one gram of commercial cake yeast, there are 20 to 24 billion individual yeast cells; in a package of dry yeast, there are 130 billion. By comparison, a cup of sourdough culture as it comes from the refrigerator contains far fewer cells. This book emphasizes repeatedly that you should never use baker’s yeast either in your sourdough culture or in the recipe of your sourdough bread. The addition of baker’s yeast to a culture may overwhelm the wild yeast and destroy the culture. In addition, you risk the introduction of a bacteriophage, or virus, to which the commercial cells are immune but which may kill wild yeast. Plus, if you leaven your dough with baker’s yeast, the open texture characteristic of sourdough may disappear.
 
The primary secret of sourdough success lies in the art of stimulating a wild culture, just before you use it in baking, into a burst of activity to equal the number of yeast cells found in commercial yeast. The steps we describe to prepare and proof a culture in this book lead to that burst of activity and ensure you will get all the leavening power your loaf needs without the addition of commercial yeast.
 
 
Research into Wild Sourdough Cultures
 
Bakers of every sort welcomed the introduction of commercial yeast in the late 1800s. It greatly simplified the baking process and made it much faster. But something happened to the sourdough flavor. It disappeared! In due time, researchers identified the problem. They found that sourdough bread is the product of not one microorganism but two: wild yeasts make it rise and beneficial bacteria provide the flavor. These bacteria are primarily lactobacilli, so named because they produce lactic acid, which contributes to the sour flavor. But what lactobacilli do, they don’t do very fast. It requires approximately twelve hours for the bacteria to develop fully the authentic taste of sourdough, depending on the temperature of the dough. Extremely fast commercial yeasts, particularly active dry yeast, have shortened the rising process to two hours or less, hardly giving the lactobacilli a chance to get started.
 
Lactobacilli produce the flavor of sourdough breads by fermentation, which is the primary reason sourdoughs are completely different from, and better than, most commercial breads. Fermentation is that process by which a variety of bacterial organisms act on food products to produce different flavors, textures, and aromas. Examples include the fermentation of milk to produce cheese, yogurt, sour cream, and buttermilk. Many types of sausage involve fermentation of various meats. Fermentation is also essential in the production of various vegetable preparations, including pickles, sauerkraut, olives, and a host of dishes from every corner of the earth. Finally, of course, wine and beer are made through the process of fermentation. But few of us are aware that fermentation is essential to the flavor of sourdoughs. Without sufficient time for that process to occur, the flavor will be lost.
 
Lactobacilli that produce the famous taste of San Francisco sourdough have been studied by Leo Kline and T. F. Sugihara, two food scientists working at the Western Regional Laboratory of the Department of Agriculture in Albany, California. They determined that many bakeries in the area were using sourdough colonized by identical strains of yeast and lactobacilli. The widespread occurrence of these organisms was not because the bakeries shared their starters with one another, but because these organisms are dominant throughout the San Francisco area. This led them to name this strain of bacteria Lactobacillus sanfrancisco. In 1970 and 1971, they published the results of their studies on San Francisco sourdough in The Bakers Digest and Applied Microbiology.
 
Kline and Sugihara identified for the first time the wild yeast Torulopsis holmii (later reclassified as Candida milleri, now as Candida humilis) as the wild yeast responsible for the sourdough process and provided instructions for producing it. The yeast also has an unusual characteristic: it is unable to utilize maltose, one of the carbohydrates found in flour. This assumes special significance, since the lactobacilli require the maltose unused by the yeast. Thus a symbiosis arises between the two organisms in the medium of hydrated flour. Further evidence indicates that the lactobacilli produce an antibiotic that protects the culture from contamination by harmful bacteria. This strong mutual dependence is thought to be responsible for the survival of the culture in San Francisco bakeries for more than one hundred years. It also explains why the culture successfully resists contamination when used in other areas. In 1973, Kline and Sugihara applied for and received a patent based on those studies so that, in the words of the patent, “the unique product (San Francisco sourdough) can be manufactured efficiently, economically and in any location regardless of climate or topography.”

Most helpful customer reviews

189 of 192 people found the following review helpful.
best sourdough reference hands down
By Vascular Ehlers-Danlos Syndrome
I looked at many other sourdough cookbooks and only found one other that did not list recipes asking for commercial bakers yeast. I wanted real sourdough recipes so selected this book and "Wild Bread: Hand-baked sourdough artisan breads in your own kitchen" by Lisa Rayner. This book has far more recipes than the book by Lisa Rayner. It is nice to have both selections but if I had to select only one, this would be the one I would pick and is the one I recommend to close friends just getting started using sourdough. The recipe selection is fantastic.

The only thing I could see missing from this book was dessert items but those can be found on the web. The chocolate sourdough cake recipe offered by King Arthur Flour Company's web-site is very good as long as you know they are looking for starter with a thick pancake batter consistency.

I was really glad to have a copy of this book after getting my starter. It really helped answer the question of, "Now what do I do with it?" I am very anxious to try the waffle recipes. I can say the pizza dough recipe turned out better than the previous recipes I have tried and the challah recipe makes one huge challah.

I don't see a need for the proofing box Wood recommends, particularly during the warmer months but otherwise I am loving this book. He does not suggest fancy equiptment and the recipes so far have been excellent.

Honestly, a canning jar with starter and a copy of this book would be an excellent gift for those who enjoy baking and those who enjoy a healthy lifestyle.

Update: Jan 2013, still using this book and a Danish dough wisk and the King Arthur flour sourdough starter stored in the King Arthur sourdough crock. I mostly use the no knead recipe as it is so easy with a Danish dough wisk. The wisk was an amazon purchase too.

98 of 102 people found the following review helpful.
A great starter
By William Steck
Had been baking my own bread for a couple of years and wanted to try baking with true sourdoughs. With this book and the Sanfrancisco starter sold on the author's website, was able to activate the starter and bake some wonderful breads. Don't think I'll ever be going back to baking with commercial yeast.

The book was quite readable and contained information that you just won't easily find anywhere else. Wood discusses different grains, gives tips on how to bring your starter back if it goes south, describes different starters, and provides a nice collection of recipes. If you are going to experiment with sourdough, this is a book you'll turn to again and again.

As an aside, the San Francisco sourdough culture makes a great bread, but I'm itching to try the Russian starter that according to Wood works well with whole wheat. Will update this review once I receive that order and turn out a few trial loaves.

Hard pressed to say if this book, or the one by Lisa Rayner is the absolute best one on the market for sourdoughs. They both have their great points. I'd go out on a limb though and say that if I could buy just one, this would be it. Read the book, order a starter. You'll soon be enjoying breads with wonderful crust and a chewy texture that just can't be duplicated with commercial yeast.

Update: One of the big challenges for me is making a palatable whole wheat bread with more than 50% whole wheat. Anything more than that and it's likely you will get a heavy, flat, dense bread. My San Francisco sourdough had that limitation as well. Last week I tried a Russian sourdough culture. Made two loaves that were 100% whole wheat. The loaves rose well and were not dense. For me that's a big milestone. Now I want to go from a completely whole wheat bread to incorporating the ancient grains such as Einkorn, Emmer, and Spelt. Should be even better for me, nutrition wise. (Emmer and Spelt IIRC have higher amounts of proteins, phosphorous, and etc.)

66 of 67 people found the following review helpful.
Still my favorite sourdough book!
By Mimmi Deutsch
This is an excellent reference for home bakers who want to understand how to create authentic sourdough breads. It's not complicated and does not require any special equipment. The original edition of this book has long been one of my favorites, and I really like the updated information in the revised edition.

One of the biggest improvements is the simplified directions in the chapter "Putting It All Together". In my opinion this is the heart of the book. In just a few pages it explains very clearly what is happening in your sourdough culture and how to handle it correctly. It made me a better baker, and I am having more fun experimenting with recipes and adapting them to my taste.

Another great addition is the "No-Knead Sourdough" recipe section. I was intrigued by the simplicity of the basic recipe. It worked beautifully for me. And with a slight adjustment to the loaf proof (lower temperature, longer time) I can now easily fit baking fresh sourdough bread into my weekday work schedule. The recipe worked equally well for rye bread.

My favorite recipe section in the book is probably also the most unique - the one on Middle Eastern breads. It's brought to life by the authors' personal experiences from living and traveling in the Middle East. I love making fresh "Khbuz Arabi" (pita bread) when we have guests. They bake in just 5 minutes, the guests love watching them puff up, and they are delicious hot out of the oven. For a perfectly authentic version, and extra food for conversation, you could use the author's "La Giza" culture, collected from an ethnic bakery in Egypt.

At the end of the book is a small section that describes the sourdough cultures collected by the authors and available on their website (Sourdoughs International). It does not come across as a pitch but rather as sharing their passion for the history and variety of sourdough cultures.

I grew up in Germany on excellent rye and whole grain sourdough breads. Many years ago when I moved to the US and experienced serious bread withdrawal, I got Ed Wood's "New Zealand Culture for rye" and have been baking with it ever since. It makes fantastic rustic rye breads, though I tend to omit the extra ingredients (molasses, milk, and butter) listed in the book's rye recipes. Now Ed Wood has a new Polish rye sourdough culture and I am tempted to try it.

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Minggu, 21 Maret 2010

[J466.Ebook] Download PDF Ancient Mathematics (Sciences of Antiquity Series), by Serafina Cuomo

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Ancient Mathematics (Sciences of Antiquity Series), by Serafina Cuomo

The theorem of Pythagoras, Euclid's "Elements", Archimedes' method to find the volume of a sphere: all parts of the invaluable legacy of ancient mathematics. But ancient mathematics was also about counting and measuring, surveying land and attributing mystical significance to the number six.
This volume offers the first accessible survey of the discipline in all its variety and diversity of practices. The period covered ranges from the fifth century BC to the sixth century AD, with the focus on the Mediterranean region. Topics include:
* mathematics and politics in classical Greece
* the formation of mathematical traditions
* the self-image of mathematicians in the Graeco-Roman period
* mathematics and Christianity
* and the use of the mathematical past in late antiquity.

  • Sales Rank: #1577638 in Books
  • Published on: 2001-09-09
  • Released on: 2001-09-09
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.43" h x .69" w x 5.43" l, .85 pounds
  • Binding: Paperback
  • 304 pages

Review

'Nicely written, expertly researched.' - Times Literary Supplement

'Ancient Mathematics provides a rich and diverse picture of mathematics in ancient Greece and Rome. With C. history of mathematics sheds its ahistoricity and gets its hands dirty.' - Journal of Roman Studies

'This book is engagingly written; and it is a pleasure to entrust oneself to Cuomo's choices.' - Aestimatio: Critical Reviews in the History of Science

About the Author
S. Cuomo is a lecturer at the Centre for the History of Science, Technology and Medicine at Imperial College, London. She is the author of a book on Pappus, and of articles on Hero and Frontinus.

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10 of 10 people found the following review helpful.
Ancient Mathematics
By Sam Adams
This book is not so much a history of ancient Greek mathematicians and their work (although that is part of it) as it is a sociological study of how mathematics was present as a cognitive method and how it was applied for practical and social purposes in ancient Greece and Rome. It is a look at how mathematics was used as a means of structuring the mental, physical, and social life during that period. If your interest is principally in the mathematics of ancient Greek mathematicians, then the book may seem diffuse and beside the point. It is, though, a clearly written and reflective book, and it brings into focus how mathematics is ever present and how it pervades our lives.

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Sabtu, 20 Maret 2010

[Q842.Ebook] Free PDF The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee

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The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee

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The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee

The Emperor of All Maladies is a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence.

Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.

The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.”

The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.

Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

  • Sales Rank: #27165 in Books
  • Brand: Simon & Schuster
  • Published on: 2010-11-16
  • Released on: 2010-11-16
  • Ingredients: Example Ingredients
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.25" h x 1.60" w x 6.12" l, 1.96 pounds
  • Binding: Hardcover
  • 592 pages

Amazon.com Review
Amazon Best Books of the Month, November 2010: "In 2010, about six hundred thousand Americans, and more than 7 million humans around the world, will die of cancer." With this sobering statistic, physician and researcher Siddhartha Mukherjee begins his comprehensive and eloquent "biography" of one of the most virulent diseases of our time. An exhaustive account of cancer's origins, The Emperor of All Maladies illustrates how modern treatments--multi-pronged chemotherapy, radiation, and surgery, as well as preventative care--came into existence thanks to a century's worth of research, trials, and small, essential breakthroughs around the globe. While The Emperor of All Maladies is rich with the science and history behind the fight against cancer, it is also a meditation on illness, medical ethics, and the complex, intertwining lives of doctors and patients. Mukherjee's profound compassion--for cancer patients, their families, as well as the oncologists who, all too often, can offer little hope--makes this book a very human history of an elusive and complicated disease. --Lynette Mong

From Publishers Weekly
Starred Review. Mukherjee's debut book is a sweeping epic of obsession, brilliant researchers, dramatic new treatments, euphoric success and tragic failure, and the relentless battle by scientists and patients alike against an equally relentless, wily, and elusive enemy. From the first chemotherapy developed from textile dyes to the possibilities emerging from our understanding of cancer cells, Mukherjee shapes a massive amount of history into a coherent story with a roller-coaster trajectory: the discovery of a new treatment--surgery, radiation, chemotherapy--followed by the notion that if a little is good, more must be better, ending in disfiguring radical mastectomy and multidrug chemo so toxic the treatment ended up being almost worse than the disease. The first part of the book is driven by the obsession of Sidney Farber and philanthropist Mary Lasker to find a unitary cure for all cancers. (Farber developed the first successful chemotherapy for childhood leukemia.) The last and most exciting part is driven by the race of brilliant, maverick scientists to understand how cells become cancerous. Each new discovery was small, but as Mukherjee, a Columbia professor of medicine, writes, "Incremental advances can add up to transformative changes." Mukherjee's formidable intelligence and compassion produce a stunning account of the effort to disrobe the "emperor of maladies." (Nov.) (c)
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From Booklist
*Starred Review* Apparently researching, treating, and teaching about cancer isn’t enough of a challenge for Columbia University cancer specialist Mukherjee. He was also moved to write a biography of a disease whose name, for millennia, could not be uttered. The eminently readable result is a weighty tale of an enigma that has remained outside the grasp of both the people who endeavored to know it and those who would prefer never to have become acquainted with it. An unauthorized biography told through the voices of people who have lived, toiled, and, yes, died under cancer’s inexorable watch. Mukherjee recounts cancer’s first known literary reference—hence its birth, so to speak—in the teachings of the Egyptian physician Imhotep in the twenty-fifth century BCE, in which it is clear that Imhotep possessed no tools with which to treat what appears to be breast cancer. His cryptic note under “Therapy:” “There is none.” Throughout cancer’s subsequent years, many more physicians and scientists with names both familiar and obscure attempted and occasionally succeeded in deciphering or unlocking keys to many of the disease’s mysteries. Alas, this is not a posthumous biography, but it is nonetheless a surprisingly accessible and encouraging narrative. --Donna Chavez

Most helpful customer reviews

1207 of 1267 people found the following review helpful.
OFF THE CHARTS
By Kenneth E. MacWilliams
You remember the scene in the film "Butch Cassidy and the Sundance Kid"? From the top of the bluff looking into the distance at dusk, Butch sees the lights of the pursuing posse which doesn't stop tracking them even at night and says "How many are following us? They're beginning to get on my nerves. Who are those guys?" In the same threatening way cancers have been dogging human beings since the dawn of time, and although we now know quite a lot about cancer we still don't really know "who are those guys" or how to shake them. And they sure are "beginning to get on our nerves" as Butch said. Almost one out of four of us will eventually wrestle with cancer -- the defining illness of our generation -- and lose our lives in the process. Until it catches up with us most of us will try to ignore this fact, just as when we were very young children alone in our bedroom trying to go to sleep at night we tried to ignore the monster that we sometimes feared might be lurking in our bedroom closet.

Enter oncologist Siddhartha Mukherjee who almost parentally takes us by the hand to give us the courage to open with him the door to that dark and foreboding closet in order to see what is really lurking inside. Since eventually most of us are going to have to wrestle with this monster anyway -- either as a victim or as a loved one of a victim -- looking intelligently and closely into that dark closet does diminish fear and enhance wise perspective. And on this incredible journey into the depths of that darkness, what an absolutely marvelous guide is this modern day Virgil called Siddharta Mukherjee as he leads us on this long and often harrowing journey through the swarth that cancer has cut through mankind throughout time.

Mukherjee is a veritable kaleidoscope. Turn his writing one way and you experience him as an exciting writer of page-turning detective stories or mystery stories; turn him another and he's a highly effective communicator of cellular biology; turn him a third and you get superb science writing; turn him a fourth and he has the grandeur and broad sweep of an excellent historian. It's hard to believe that this one book, combining all of these appealing characteristics, is the work of just one man. And underlying it all is his sterling medical training and credentials which have been enumerated often elsewhere.

The book itself is a tour de force. It is the first book of such extraordinary scope regarding cancer. Its architectural structure brings to mind Melville's Moby Dick and how effectively and artfully Melville braided together the three strands of his great classic: a grand adventure story, the technology of whaling, and a treatise of humanity and philosophy. Equally effectively does Mukherjee weave together all the various facets of this iconic disease throughout history, from describing cancer from the patient's perspective, to viewing the never ending battles of physicians and medical researchers with cancer over the centuries, to examining the mysteries of the cellular nature of cancer itself and what really goes on in there, to the pro and con impact of this never ending plague on the spirit of the individual human and on our race as a whole, to peering into a crystal ball for a glance of cancer's and our future together. While doing all of this the alchemy of Mukherjee's writing continually turns science into poetry and poetry into science.

Simply put, it is so good, and so incandescently clear and lucid, and so powerful, and so engrossing, and so easily consumed that you will not lay it down without someone or circumstances forcing you to.

Had I read this book in my teens I would have found my life's career. I can only imagine that while you are reading this book, somewhere there will be some very young teenage girl or boy who will also be reading it at the same time you are, and who will become totally hooked by this book just as you will be, and who will go on to make a career in cancer research, a career that might provide the breakthrough that humanity has been searching and hoping for all of these many centuries. Thus although you will never know it, you will have "been there" at the initial motivation of that person and thus indirectly present at the earliest genesis of the eventual great idea.

This book has THAT potential. It is THAT good.

Kenneth E. MacWilliams

1 of 1 people found the following review helpful.
read it after your treatment
By Aaron McLoughlin
Last April I was diagnosed with acute leukaemia. After a stem cell transplant I am coming up for a year.

When you are told you have cancer you are bewildered. You are also very angry. I asked myself was there something I had done in my past that was going to deprive me seeing my two sons grow up into happy young men and dads. The first two weeks go by in a weird nightmare. Day 17 your hair falls out. Your peeing orange from the chemo drugs, which have put me off lucozade for life. You double check all your insurances are up to date and update a well to make sure my wife does not have any hassles with the tax authorities. At the age of 44 you are very angry. You realise you are likely going to die. You are angry because you have no idea what is doing it. What you planned for when you were older is all meaningless. But, thanks to certain stubbornness and amazing treatment and care, and a generous sift of life from a German donor of life giving stem cells, I am alive.

This book helps explain many of the questions I had. It does it in a way that makes sense if you don't have a degree in science. What was until recently a death sentence is no longer the case. The battle against cancer was waged by intrepid individuals, and this book explains the war so far. It outlines the causes of cancer, whether it is a virus, bacteria, induced by smoking or chemicals, or just our own body playing up and turning on itself. It explains how our own understanding is still basic but advancing year by year, and treatments, if not cures, are being found for many, although not all cancers.

I learned that was once a death sentence is not the case today. I am looking forward to see my sons become men. This book gave me clarity, it gave me hope.

2 of 2 people found the following review helpful.
An insider's view of cancer
By Ionut Trestian
I only read this book because Ken Burns produced a documentary on it that is coming out in the Spring of 2015. I really love Ken Burns documentaries, hence the interest. Across the book, there is only one common character, cancer. Although cancer is not a single disease but a collection of several diseases characterized by uncontrolled growth and spread of cells in the body, the book portrays cancer as a great villain, lurking in the shadows, ready to strike at any time. What makes this story different and far from dry is the way S. Mukherjee tells it: "the story of leukemia - the story of cancer - isn't the story of doctors who struggle and survive, moving from one institution to another. It is the story of patients who struggle and survive, moving from one embankment of illness to another. Resilience, inventiveness, and survivorship — qualities often ascribed to great physicians — are reflected qualities, emanating first from those who struggle with illness and only then mirrored by those who treat them. If the history of medicine is told through the stories of doctors, it is because their contributions stand in place of the more substantive heroism of their patients."

Across the book, we are also introduced to ways of fighting or stalling the advance of cancer: radical surgery and radical mastectomy, X-rays, cytotoxics, monoclonal antibodies, tyrosine kinase inhibitors and S. Mukherjee explains really well how all of the above function (or don't function in some cases). One of the strengths of the book is that it gives a behind the scenes look at how certain drugs or procedures came to be (Druker's struggles with developing imatinib) or how other procedures were proven to be too radical and changed such as Halsted's radical mastectomy.

The fight to find a cure for cancer has triggered enormous social forces in the 20th century and in the book we are introduced to some of the main characters: Sidney Farber and the Jimmy Fund, Mary Lasker and the American Cancer Society both determined to enact policy changes that will get more resources allocated to the war against cancer. These are just a few figures in this war, but there were other forces as well that fought for cigarette labeling for example, or more personal struggles related to compassionate drug use.

S. Mukherjee ends the book on a more positive note. All throughout the book we get the impression that primitive forces are battling a very complex disease, using disfiguring surgery or drugs that oftentimes end up causing cancer themselves. The final few chapters are not so gloomy, he takes a molecular biologist's view of the disease and explains our current understanding of the processes and pathways involved and you do get the impression that by 2050 we will be able to target the specific pathways and mutations that make up a particular form of cancer.

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Rabu, 17 Maret 2010

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Saul Bass: A Life in Film & Design (Hardback) - Common, by , by (author) Pat Kirkham, Foreword

This is the first book to be published on one of the greatest American designers of the 20th century, who was as famous for his work in film as for his corporate identity and graphic work. Designed by Saul Bass's daughter Jennifer and written by distinguished design historian Pat Kirkham, this book contains more than 1,400 illustrations.

  • Published on: 2012
  • Binding: Hardcover
  • 440 pages

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Senin, 01 Maret 2010

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  • Sales Rank: #545171 in eBooks
  • Published on: 2015-03-13
  • Released on: 2015-03-13
  • Format: Kindle eBook

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